asiabet88()

T- bet 是2000 年哈佛大学Glimcher 研究小组分离出的T- box 基因家族的新型转录因子，选择性地表达于Th1 细胞，含530 个氨基酸，其中189 个氨基酸是T- box结合结构域，人类T- bet 与鼠T- bet 氨基酸有88%的同源性。
Th 是免疫反应中重要的调控/ 效应细胞，可分为Th1 及Th2 型，正常情况下，其功能和数量处于平衡状态。Th1、Th2 是由共同的前体细胞Th0 分化而来，而转录因子T- bet 和GATA- 3 是特异性调控Th0 分化、起着Th1/Th2 转换开关作用的关键因子。从来自Th1 细胞系的PL17、OF6、AE7 及来自Th2 细胞系的CD35、CD10的RNA 免疫印迹分析显示，T- bet 转录只出现于Th1 细胞系，，认为T- bet 选择性表达于Th1 细胞，只限于肺、胸腺和脾脏，其表达水平通过T 细胞受体（TCR）介导的信号传导而增强。另有研究表明T- bet 除表达于CD4+ Th1 细胞和NK 细胞外，也可表达于非淋巴细胞，如树突状细胞（DC），巨噬细胞在IFN- γ 的诱导下也能表达T- bet，而且经IFN- γ 刺激后所表达的T- bet 水平明显高于NK 细胞所表达的T- bet。T- bet 作为Th1特异的转录因子，选择性表达于Th1 细胞，通过启动Th1 遗传程序在Th1 细胞的发育中起重要作用，并且抑制Th2 细胞因子的合成。

牒一
ARASHI_AROUND_ASIA台字DISK1_1.avi f46d41a5fb
ARASHI_AROUND_ASIA台字DISK1_2.avi f4f408b70b
ARASHI_AROUND_ASIA台字DISK1_3.avi t1650918e2
ARASHI_AROUND_ASIA台字DISK1_4.avi t1d13f8351
ARASHI_AROUND_ASIA台字DISK1_5.avi t1c2249fd7

牒二
ARASHI_AROUND_ASIA台字DISK2_1.avi t1ce48cfd6
ARASHI_AROUND_ASIA台字DISK2_2.avi t1a0785b4
ARASHI_AROUND_ASIA台字DISK2_3.avi t172f792d1
ARASHI_AROUND_ASIA台字DISK2_4.avi t172174ba8
ARASHI_AROUND_ASIA台字DISK2_5.avi t1a948e61c

牒三
ARASHI_AROUND_ASIA台字DISK3_1.avi t1710b1207
ARASHI_AROUND_ASIA台字DISK3_2.avi t124ecdb13
ARASHI_AROUND_ASIA台字DISK3_3.avi t1807ea9b7
ARASHI_AROUND_ASIA台字DISK3_4.avi f1e3b203b6
ARASHI_AROUND_ASIA台字DISK3_5.avi f170a2b7dc
07年DOME 凯旋
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